2026-04-18T00:22:58Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1038822025-12-04T19:33:05Zcom_2072_1057col_2072_478908col_2072_478917

00925njm 22002777a 4500 dc Tauriello, Daniele V. F. author Calon, Alexandre author Lonardo, Enza author Batlle, Eduard author 2016-11-18T10:52:10Z 2016-11-18T10:52:10Z 2016-10-28 2016-11-18T10:46:46Z Colorectal cancer (CRC) is one of the most common cancer types and represents a major therapeutic challenge. Although initial events in colorectal carcinogenesis are relatively well characterized and treatment for early‐stage disease has significantly improved over the last decades, the mechanisms underlying metastasis – the main cause of death – remain poorly understood. Correspondingly, no effective therapy is currently available for advanced or metastatic disease. There is increasing evidence that colorectal cancer is hierarchically organized and sustained by cancer stem cells, in concert with various stromal cell types. Here, we review the interplay between cancer stem cells and their microenvironment in promoting metastasis and discuss recent insights relating to both patient prognosis and novel targeted treatment strategies. A better understanding of these topics may aid the prevention or reduction of metastatic burden. Càncer colorectal Cèl·lules mare Colorectal cancer Stem cells Determinants of metastatic competency in colorectal cancer