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Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands Salomó i Prat, Ernest Orgué Gassol, Sílvia Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier Compostos fosforosos Lligands (Bioquímica) Phosphorus compounds Ligands (Biochemistry) A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*. 2016-09-22T10:03:10Z 2017-03-22T23:01:24Z 2016-03-22 2016-09-22T10:03:15Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: http://dx.doi.org/10.1055/s-0035-1561854 Synthesis. Journal of Synthetic Organic Chemistry, 2016, vol. 48, num. 16, p. 2659-2663 http://dx.doi.org/10.1055/s-0035-1561854 (c) Georg Thieme Verlag, 2016 info:eu-repo/semantics/openAccess Georg Thieme Verlag Articles publicats en revistes (Química Inorgànica i Orgànica)