2026-04-17T04:25:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1020672025-11-19T20:55:00Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Salomó i Prat, Ernest author Orgué Gassol, Sílvia author Riera i Escalé, Antoni author Verdaguer i Espaulella, Xavier author 2016-09-22T10:03:10Z 2017-03-22T23:01:24Z 2016-03-22 2016-09-22T10:03:15Z A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*. Compostos fosforosos Lligands (Bioquímica) Phosphorus compounds Ligands (Biochemistry) Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands