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Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides Salomó i Prat, Ernest Orgué Gassol, Sílvia Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier Hidrogenació Catàlisi asimètrica Enantiòmers Hydrogenation Enantioselective catalysis Enantiomers The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the redn. of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: in most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and Et acetate, with no loss of selectivity. 2016-09-20T15:49:47Z 2016-09-20T15:49:47Z 2016-05-17 2016-09-20T15:49:52Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1002/anie.201602219 Angewandte Chemie International Edition, 2016, vol. 55, p. 7988-7992 http://dx.doi.org/10.1002/anie.201602219 cc-by-nc (c) Salomó et al., 2016 http://creativecommons.org/licenses/by-nc/3.0/es info:eu-repo/semantics/openAccess Wiley Articles publicats en revistes (Química Inorgànica i Orgànica)