2026-04-05T10:39:28Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/908352025-07-17T05:47:07Zcom_2072_1033col_2072_452950

Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy Gabriel, Ramirez Proctor, Ashley R. Jung, Ki Won Wu, Tong Tong Han, Songfeng Adams, Russell R. Ren, Jingxuan Byun, Daniel K. Madden, Kelley S. Brown, Edward B. Foster, Thomas H. Farzam, Parisa Durduran, Turgut Choe, Regine Àrees temàtiques de la UPC::Física spectroscopy Medical optics and biotechnology Òptica The non-invasive, in vivo measurement of microvascular blood flow has the potential to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast cancer (N=125) under chemotherapy was quantified with diffuse correlation spectroscopy based on layer models. Six different treatment regimens involving doxorubicin, cyclophosphamide, and paclitaxel at clinically relevant doses were investigated. Treatments with cyclophosphamide increased blood flow as early as 3 days after administration, whereas paclitaxel induced a transient blood flow decrease at 1 day after administration. Early blood flow changes correlated strongly with the treatme Peer Reviewed Postprint (published version) 2016-09-01 Article https://www.osapublishing.org/boe/abstract.cfm?uri=boe-7-9-3610 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access Attribution-NonCommercial-NoDerivs 3.0 Spain OSA