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The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks Gomez Orlandi, Javier Álvarez Lacalle, Enrique Teller Amado, Sara Casademunt Viader, Jaume Soriano Fradera, Jordi Universitat Politècnica de Catalunya. Departament de Física Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos Àrees temàtiques de la UPC::Enginyeria de la telecomunicació::Telemàtica i xarxes d'ordinadors Neural networks (Computer science) Xarxes neuronals (Informàtica) -- Aplicacions Cultured neurons in vitro quickly connect to one another to establish a spontaneously active network within a week. The resulting neuronal network is char- acterized by a combination of excitatory and inhibitory integrate–and–fire units coupled through synaptic connec- tions, and that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons’ membrane potential and synaptic transmission, together with intrinsic biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including periodic spontaneous activ- ity, avalanches, propagation of activity fronts, and synchro- nization. Here we describe some experimental results on spontaneous activity in cultures, and elaborate on theoreti- cal models that describe its initiation and maintenance Peer Reviewed Postprint (published version) 2012-10 Article Orlandi, J., Alvarez-Lacalle, E., Teller, S., Casademunt, J., Soriano, J. The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks. "Proceedings of 2012 International Symposium on Nonlinear Theory and its Applications", Octubre 2012, vol. 1, p. 547-550. 2188-5079 https://hdl.handle.net/2117/86183 10.15248/proc.1.547 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access 4 p. application/pdf