2026-04-13T18:06:01Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/829492026-02-07T09:30:48Zcom_2072_1033col_2072_452950

Manifold learning visualization of metabotropic glutamate receptors Cárdenas Domínguez, Martha Ivón Vellido Alcacena, Alfredo Giraldo Arjonilla, Jesús Universitat Politècnica de Catalunya. Departament de Ciències de la Computació Universitat Politècnica de Catalunya. SOCO - Soft Computing Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica Protein research G-protein-coupled receptors Metabotropic glutamate receptors Data visualization Generative topographic mapping Proteïnes -- Investigació G-Protein-Coupled Receptors (GPCRs) are cell membrane proteins with a key role in biological processes. GPCRs of class C, in particular, are of great interest in pharmacology. The lack of knowledge about their 3-D structures means they must be investigated through their primary amino acid sequences. Sequence visualization can help to explore the existing receptor sub-groupings at different partition levels. In this paper, we focus on Metabotropic Glutamate Receptors (mGluR), a subtype of class C GPCRs. Different versions of a probabilistic manifold learning model are employed to comparatively sub-group and visualize them through different transformations of their sequences. Peer Reviewed Postprint (author's final draft) 2014 Conference report Cárdenas, M.I., Vellido, A., Giraldo, J. Manifold learning visualization of metabotropic glutamate receptors. A: International Conference of the Catalan Association for Artificial Intelligence. "Artificial Intelligence Research and Development: Proceedings of the 17th International Conference of the Catalan Association for Artificial Intelligence, Barcelona, Catalonia, Spain, October 22-24, 2014". Barcelona: IOS Press, 2014, p. 269-272. 978-1-61499-451-0 https://hdl.handle.net/2117/82949 10.3233/978-1-61499-452-7-269 eng http://ebooks.iospress.nl/publication/38078 Open Access 4 p. application/pdf IOS Press