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oai:recercat.cat:2117/829232026-01-30T03:15:49Zcom_2072_1033col_2072_452950

A weighted Cramér’s V Index for the assessment of stability in the fuzzy clustering of class C G protein-coupled receptors Vellido Alcacena, Alfredo Halka, Christiana Nebot Castells, M. Àngela Universitat Politècnica de Catalunya. Departament de Ciències de la Computació Universitat Politècnica de Catalunya. SOCO - Soft Computing Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica Protein research Fuzzy clustering K-Means Clustering stability analysis Cramér’s V index G Protein-Coupled Receptors Proteïnes -- Investigació After decades of intensive use, K-Means is still a common choice for crisp data clustering in real-world applications, particularly in biomedicine and bioinformatics. It is well-known that different initializations of the algorithm can lead to different solutions, precluding replicability. It has also been reported that even solutions with very similar errors may widely differ. A criterion for the choice of clustering solutions according to a combination of error and stability measures has recently been suggested. It is based on the use of Cramér’s V index, calculated from contingency tables, which is valid only for crisp clustering. Here, this criterion is extended to fuzzy and probabilistic clustering by first defining weighted contingency tables and a corresponding weighted Cramér’s V index. The proposed method is illustrated using Fuzzy C-Means in a proteomics problem. Peer Reviewed Postprint (author's final draft) 2015 Conference report Vellido, A., Halka, C., Nebot, M. A weighted Cramér’s V Index for the assessment of stability in the fuzzy clustering of class C G protein-coupled receptors. A: International Work-Conference on Bioinformatics and Biomedical Engineering. "Bioinformatics and Biomedical Engineering: Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015: proceedings, part I (LNCS; 9043)". Granada: Springer, 2015, p. 536-547. 978-3-319-16482-3 https://hdl.handle.net/2117/82923 10.1007/978-3-319-16483-0_52 eng http://link.springer.com/chapter/10.1007/978-3-319-16483-0_52 Open Access 12 p. application/pdf Springer