2026-04-13T13:31:50Zhttps://recercat.cat/oai/requestoai:recercat.cat:2117/822182026-01-24T05:36:22Zcom_2072_1033col_2072_452950
Sarcomere disruptions of slow fibres resulting from mountain ultramarathon
Mountain ultramarathon and sarcomere disruptions of slow fibers
Carmona, Gerard
Roca, Emma
Guerrero, Mario
Cussó, Roser
Irurtia Amigo, Alfredo
Nescolarde Selva, Lexa Digna
Brotons, Daniel
Bedini, José Luis
Cadefau, Joan
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana
Sports injuries
Muscles
Racing
Runners (Sports)
Creatine kinase
Músculs
Esports--Lesions
Curses
Corredors (Esports)
Creatina quinasa
Objective: To investigate changes after a mountain ultramarathon (MUM) in the serum concentration of fast (FM) and slow (SM) myosin isoforms, which are fiber-type-specific sarcomere proteins. The changes were compared against creatine kinase (CK), a widely used fiber-sarcolemma-damage biomarker, and cardiac troponin I (cTnI), a widely used cardiac biomarker. Methods: Observational comparison of response in a single group of 8 endurance-trained amateur athletes. Time-related changes in serum levels of CK, cTnI, SM, and FM from competitors were analyzed before, 1 h after the MUM, and 24 and 48 h after the start of the MUM by 1-way ANOVA for repeated measures or Friedman and Wilcoxon tests. Pearson correlation coefficient was employed to examine associations between variables. Results: While SM was significantly (P = .009) increased in serum 24 h after the beginning of the MUM, FM and cTnI did not change significantly. Serum CK activity peak was observed 1 h after the MUM (P = .002). Moreover, serum peaks of CK and SM were highly correlated (r = .884, P = .004). Conclusions: Since there is evidence of muscle damage after prolonged mountain running, the increase in SM serum concentration after a MUM could be indirect evidence of slow- (type I) fiber-specific sarcomere disruptions.
Peer Reviewed
Postprint (published version)
2015-11-02
Article
Open Access