2026-04-13T07:00:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/822182026-01-24T05:36:22Zcom_2072_1033col_2072_452950

urn:hdl:2117/82218 Sarcomere disruptions of slow fibres resulting from mountain ultramarathon Mountain ultramarathon and sarcomere disruptions of slow fibers Carmona, Gerard Roca, Emma Guerrero, Mario Cussó, Roser Irurtia Amigo, Alfredo Nescolarde Selva, Lexa Digna Brotons, Daniel Bedini, José Luis Cadefau, Joan Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Anatomia i fisiologia humana Sports injuries Muscles Racing Runners (Sports) Creatine kinase Músculs Esports--Lesions Curses Corredors (Esports) Creatina quinasa Objective: To investigate changes after a mountain ultramarathon (MUM) in the serum concentration of fast (FM) and slow (SM) myosin isoforms, which are fiber-type-specific sarcomere proteins. The changes were compared against creatine kinase (CK), a widely used fiber-sarcolemma-damage biomarker, and cardiac troponin I (cTnI), a widely used cardiac biomarker. Methods: Observational comparison of response in a single group of 8 endurance-trained amateur athletes. Time-related changes in serum levels of CK, cTnI, SM, and FM from competitors were analyzed before, 1 h after the MUM, and 24 and 48 h after the start of the MUM by 1-way ANOVA for repeated measures or Friedman and Wilcoxon tests. Pearson correlation coefficient was employed to examine associations between variables. Results: While SM was significantly (P = .009) increased in serum 24 h after the beginning of the MUM, FM and cTnI did not change significantly. Serum CK activity peak was observed 1 h after the MUM (P = .002). Moreover, serum peaks of CK and SM were highly correlated (r = .884, P = .004). Conclusions: Since there is evidence of muscle damage after prolonged mountain running, the increase in SM serum concentration after a MUM could be indirect evidence of slow- (type I) fiber-specific sarcomere disruptions. Peer Reviewed Postprint (published version) 2015-11-02 Article Open Access