2026-04-20T04:00:25Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/4606232026-04-19T01:17:59Zcom_2072_1033col_2072_452950

3D-StyleGAN2-ADA: Volumetric synthesis of realistic prostate T2W MRI Lezcano Giardina, Claudia Patricia Vilaplana Besler, Verónica Universitat Politècnica de Catalunya. Doctorat en Teoria del Senyal i Comunicacions Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions Universitat Politècnica de Catalunya. GPI - Grup de Processament d'Imatge i Vídeo Àrees temàtiques de la UPC::Enginyeria de la telecomunicació::Processament del senyal::Processament de la imatge i del senyal vídeo Àrees temàtiques de la UPC::Informàtica::Intel·ligència artificial::Aprenentatge automàtic Prostate MRI Generative adversarial network 3D-StyleGAN2-ADA Medical image synthesis Prostate cancer MRI augmentation This work investigates the extension of StyleGAN2-ADA to three-dimensional prostate T2-weighted (T2W) MRI generation. The architecture is adapted to operate on 3D anisotropic volumes, enabling stable training at a clinically relevant resolution of 256×256×24, where a baseline 3D-StyleGAN fails to converge. Quantitative evaluation using Fréchet Inception Distance (FID), Kernel Inception Distance (KID), and generative Precision–Recall metrics demonstrates substantial improvements over a 3D-StyleGAN baseline. Specifically, FID decreased from 114.2 to 27.3, while generative Precision increased from 0.22 to 0.82, indicating markedly improved fidelity and alignment with the real data distribution. Beyond generative metrics, the synthetic volumes were evaluated through radiomic feature analysis and downstream prostate segmentation. Synthetic data augmentation resulted in segmentation performance comparable to real-data training, supporting that volumetric generation preserves anatomically relevant structures, while multivariate radiomic analyses showed strong global feature alignment between real and synthetic volumes. These findings indicate that a 3D extension of StyleGAN2-ADA enables stable high-resolution volumetric prostate MRI synthesis while preserving anatomically coherent structure and global radiomic characteristics. This work was supported by the European project Federated Learning and mUlti-party computation Techniques for prostatE cancer (HORIZON-101095382-FLUTE), the Spanish Research Agency (AEI) under project PID2023-148614OB-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, EU, and the FPI-Ministerio PRE-2021-098481 grant. Peer Reviewed Postprint (published version) 2026-03-14 Article Giardina, C.; Vilaplana, V. 3D-StyleGAN2-ADA: Volumetric synthesis of realistic prostate T2W MRI. «Journal of imaging», 14 Març 2026, vol. 12, núm. 3, article 130. 2313-433X https://hdl.handle.net/2117/460623 10.3390/jimaging12030130 https://hdl.handle.net/2117/460623 eng https://www.mdpi.com/2313-433X/12/3/130 info:eu-repo/grantAgreement/EC/HE/101095382/EU/Federate Learning and mUlti-party computation Techniques for prostatE cancer/FLUTE info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-148614OB-I00/ES/INTELIGENCIA ARTIFICIAL CENTRADA EN DATOS PARA IMAGEN MEDICA/ http://creativecommons.org/licenses/by/4.0/ Open Access Attribution 4.0 International 21 p. application/pdf Multidisciplinary Digital Publishing Institute (MDPI)