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oai:recercat.cat:2117/4561462026-03-09T04:35:33Zcom_2072_1033col_2072_452950

Lower perturbational complexity index after transcranial magnetic stimulation in schizophrenia patients Molina Rodriguez, Vicente Fernández Linsenbarth, Inés Beño Ruiz de la Sierra, Rosa María Osorio Iriarte, Emma Roig Herrero, Alejandro Arjona Valladares, Antonio Rodríguez González, Víctor Núñez, Pablo Poza, Jesús Díez Revuelta, Alvaro Rodríguez Valbuena, Claudia Mijancos Martínez, Gema Bachiller Matarranz, Alejandro Mañanas Villanueva, Miguel Ángel Universitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial Universitat Politècnica de Catalunya. BIOART - BIOsignal Analysis for Rehabilitation and Therapy Àrees temàtiques de la UPC::Ciències de la salut Perturbational Complexity Schizophrenia Transcranial Stimulation © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Background: Informational integration and differentiation of the cortex can be tested by methods such as the perturbational complexity index (PCI) combined with TMS-induced activity perturbation. The PCI is obtained by stimulating the cortex with TMS and measuring the resulting spatiotemporal cortical responses with high-density EEG. Methods: We have compared PCI between 26 patients with schizophrenia (15 males), 15 of them First Episode (FE) (7 males), and 22 healthy controls (12 males). Results: Values of PCI were significantly lower in patients with schizophrenia, as well as in FE considered alone. There was no significant relation between anomalous self-experiences or symptoms and PCI values in the patients: PCI values were unrelated to treatment doses or illness duration. Conclusions: Our data suggest that spatiotemporal cortical responses to TMS pulses are reduced in patients regarding variability or spatial extension, which could imply a lower capacity for sustaining informational complexity. This work was supported by the following grants: ‘Instituto de Salud Carlos III’ (PI-22/00465), and Gerencia Regional de Salud de Castilla y León (GRS-2685/A1/2023) and partially supported by the “Ministerio de Ciencia e Innovación (MICINN)” (grant ID PID2020-117751RB-I00), and “Fundació La Marató de TV3” (grant ID 202219-30-31), “MICIU/AEI/10.13039/501100011033” and by “ERDF A way of making Europe” through the project PID2022-138286NB-I00, and by “CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN)” through “Instituto de Salud Carlos III“ co-funded with ERDF funds and by the ERA-Net FLAG-ERA JTC2021 project ModelDXConsciousness (Human Brain Project Partnering Project). Two research training grants by the ‘Consejería de Educacion ´ – Junta de Castilla y Leon´ ’ and the ‘European Social Fund’ (VA-223-19 and VA-183-18) were respectively awarded to PhD candidates RBRS and IFL. GMM is in receipt of a FI-2022 grant from “Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR)”. These funding sources had no other role than that of providers of financial support. Peer Reviewed Postprint (published version) 2025-03-20 Article Molina, V. [et al.]. Lower perturbational complexity index after transcranial magnetic stimulation in schizophrenia patients. «Progress in neuro-psychopharmacology and biological psychiatry», 20 Març 2025, vol. 137, núm. article 111254. 0278-5846 https://hdl.handle.net/2117/456146 10.1016/j.pnpbp.2025.111254 https://hdl.handle.net/2117/456146 eng https://www.sciencedirect.com/science/article/abs/pii/S0278584625000089 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138286NB-I00/ES/EL CEREBRO CRONECTOMICO: IDENTIFICANDO LAS HUELLAS NEUROPATOLOGICAS DE LA DEMENCIA/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117751RB-I00/ES/TECNOLOGIAS INNOVADORAS PARA MONITORIZAR Y PERSONALIZAR LA REHABILITACION INTERDISCIPLINAR DE PACIENTES DE CUIDADO INTENSIVO/ info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F00465/ES/BUSQUEDA DE BIOTIPOS VALIDOS DENTRO DEL SÍNDROME PSICÓTICO/ http://creativecommons.org/licenses/by/4.0/ Open Access Attribution 4.0 International application/pdf