2026-04-17T01:18:16Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/4467442026-01-15T04:30:42Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Mannelli, Ilaria author Reigada, Ramon author Suárez, Irina author Janner, Davide author Carrilero, A author Mazumder, Prantik author Sagués, Francesc author Pruneri, Valerio author Lakadamyali, Melike author 2016-06-22 Surfaces contaminated with pathogenic microorganisms contribute to their transmission and spreading. The development of “active surfaces” that can reduce or eliminate this contamination necessitates a detailed understanding of the molecular mechanisms of interactions between the surfaces and the microorganisms. Few studies have shown that, among the different surface characteristics, the wetting properties play an important role in reducing virus infectivity. Here, we systematically tailored the wetting characteristics of flat and nanostructured glass surfaces by functionalizing them with alkyl- and fluoro-silanes. We studied the effects of these functionalized surfaces on the infectivity of Influenza A viruses using a number of experimental and computational methods including real-time fluorescence microscopy and molecular dynamics simulations. Overall, we show that surfaces that are simultaneously hydrophobic and oleophilic are more efficient in deactivating enveloped viruses. Our results suggest that the deactivation mechanism likely involves disruption of the viral membrane upon its contact with the alkyl chains. Moreover, enhancing these specific wetting characteristics by surface nanostructuring led to an increased deactivation of viruses. These combined features make these substrates highly promising for applications in hospitals and similar infrastructures where antiviral surfaces can be crucial. Postprint (published version) Àrees temàtiques de la UPC::Enginyeria dels materials Àrees temàtiques de la UPC::Enginyeria dels materials Hydrophobicity Infectious diseases Vesicles Viruses Wetting Influenza A Wettability Hydrophobic and oleophilic surfaces Coarse-grained molecular dynamics simulations Fluorescence microscopy Nanostructured substrates Functionalized surfaces with tailored wettability determine influenza a infectivity