2026-04-13T13:13:47Zhttps://recercat.cat/oai/request
oai:recercat.cat:2117/4452982026-02-07T10:41:39Zcom_2072_1033col_2072_452950
RECERCAT author Tohà Dalmau, Ariadna author Rosinés Fonoll, Josep author Romero Merino, Enrique author Mazzanti Castrillejo, Fernando Pablo author Martín Pinardel, Rubén author Marias Perez, Sonia author Bernal Morales, Carolina author Castro Domínguez, Rafael author Méndez Mourelle, Andrea author Ortega Martínez de Victoria, Emilio author Vinagre Torres, Irene author Giménez Álvarez, Margarita author Vellido Alcacena, Alfredo author Zarranz Ventura, Javier 2025-11 Purpose: To develop a machine learning (ML) algorithm capable of determining cardiovascular (CV) risk in multimodal retinal images from patients with type 1 diabetes mellitus (T1DM), distinguishing between moderate, high, and very high-risk levels. Design: Cross-sectional analysis of a retinal image data set from a previous prospective OCT angiography (OCTA) study (ClinicalTrials.gov NCT03422965). Participants: Patients with T1DM included in the progenitor study. Methods: Radiomic features were extracted from color fundus photographs (CFPs), OCT, and OCTA images, and ML models were trained using these features either individually or combined with clinical data (demographics and systemic data, OCT + OCTA commercial software metrics, ocular data, blood data). Different data combinations were tested to determine the CV risk stages, defined according to international classifications. Main Outcome Measures: Area under the receiver operating characteristic curve mean and standard deviation for each ML model and each data combination. Results: A data set of 597 eyes (359 individuals) was analyzed. Models trained only with the radiomic features achieved area under the curve (AUC) values of (0.79 ± 0.03) to identify moderate risk cases from high and very high-risk cases, and (0.73 ± 0.07) for distinguishing between high and very high-risk cases. The addition of clinical variables improved all AUC values, obtaining (0.99 ± 0.01) for identifying moderate cases, and (0.95 ± 0.02) for differentiating between high and very high-risk cases. For very high CV risk, radiomics combined with OCT + OCTA metrics and ocular data achieved an AUC of (0.89 ± 0.02) without systemic data input. The performance of the models was similar in unilateral and bilateral eye image data sets. Conclusions: Radiomic features obtained from retinal images are helpful to discriminate and classify CV risk labels, differentiating risk categories. The addition of demographics and systemic data combined with ocular data differentiate high from very high CV risk cases, and interestingly OCT + OCTA metrics with ocular data identify very high CV risk cases without systemic data input. These results reflect the potential of this oculomics approach for CV risk assessment. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.This study was funded by Instituto de Salud Carlos III through the project PI21/01384 and co-funded by the European Union (PI: J.Z.-V.), and supported by the Spanish research grant (PID2022-143299OB-I00/AEI/ 10.13039/501100011033/FEDER, UE [A.T.-D., E.R., and A.V.]); Generalitat de Catalunya (grant Grup de Recerca SGR-Cat2021 with reference 2021SGR-01411 [F.M.]); and the Ministerio de Ciencia e Innovación MCIN/AEI/10.13039/501100011033, Spain (grant no.: PID2023- 147469NB-C21 [F.M.]).Peer ReviewedPostprint (published version) http://creativecommons.org/licenses/by-nc-nd/4.0/ Open Access Attribution-NonCommercial-NoDerivatives 4.0 International Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica Àrees temàtiques de la UPC::Informàtica::Intel·ligència artificial::Aprenentatge automàtic Cardiovascular risk Diabetes mellitus type I Machine learning Optical coherence tomography angiography Radiomics Machine learning prediction of cardiovascular risk in type 1 diabetes mellitus using radiomic features from multimodal retinal images Article