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oai:recercat.cat:2117/4217492026-01-27T02:17:22Zcom_2072_1033col_2072_452950

Obtention of scaffolds for grafts on human skin with PLA-Nano fibers and cinnamon oil-lanoline emulsions Marqués Arribas, Leyre Cota, Paula Cano Casas, Francesc Martí Gelabert, Meritxell Martínez Fernández, Alba Lis Arias, Manuel José Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials Universitat Politècnica de Catalunya. Departament d'Enginyeria Química Universitat Politècnica de Catalunya. TECTEX - Grup de Recerca en Tecnologia Tèxtil Universitat Politècnica de Catalunya. POLQUITEX - Materials Polimérics i Química Téxtil Àrees temàtiques de la UPC::Enginyeria química::Indústries químiques::Química tèxtil Electrospinning Scaffolds Cinnamon essential oil PLA Lanoline The interest in tissue engineering is growing in the scientific and medical communities, as it can solve actual problems regarding donor tissues, wound healing and drug delivery systems. Nanofibers are gaining relevance in this topic thanks to their excellent mechanical properties and similarities concerning the human skin. This project has explored how combining the nanofibers’ membranes created of PLA, made by electrospinning, with a dissolution of lanoline and cinnamon essential oil not only imitates the human skin, as it was demonstrated in a later project, but also obtains an antibacterial character. Analytical techniques such as a spectrophotometer, an electrokinetic analyzer, a scanning electron microscope, a Fourier transform infrared spectroscope, and an optical tensiometer were employed. Results confirmed successful integration and migration of the cinnamon oil, with antibacterial efficacy achieved against specific bacterial strains, as hypothesized. Notably, scaffolds composed of seven layers exhibited migration behavior closely aligned with theoretical expectations The authors acknowledge the funding to the research group TECTEX (2021 SGR 01056) by the Departament de Recerca i Universitats de la Generalitat de Catalunya Postprint (published version) 2024-12-30 Article Marqués, L. [et al.]. Obtention of scaffolds for grafts on human skin with PLA-Nano fibers and cinnamon oil-lanoline emulsions. "Journal of Composites and Biodegradable Polymers", 30 Desembre 2024, vol. 12, p. 41-51. 2311-8717 https://hdl.handle.net/2117/421749 10.12974/2311-8717.2024.12.05 eng https://savvysciencepublisher.com/index.php/jcbp/article/view/1067 http://creativecommons.org/licenses/by/4.0/ Open Access Attribution 4.0 International 11 p. application/pdf