2026-04-13T01:34:35Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/4173612026-02-11T04:44:49Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Tost Abadías, Ana author Romero Lafuente, Sergio author Alonso López, Joan Francesc author Bachiller Matarranz, Alejandro author Serna Higuita, Leidy Yanet author Medina Rivera, Inés author García Cazorla, Ángeles author Mañanas Villanueva, Miguel Ángel author 2024-07 Background: Functional connectivity is scarcely studied in Rett syndrome (RTT). Explorations revealed associations between RTT's clinical, genetic profiles, and coherence measures, highlighting an unexplored frontier in understanding RTT's neural mechanisms and cognitive processes. Aims: To evaluate the effects of diverse cognitive stimulations—learning-focused versus gaming-oriented—on electroencephalography brain connectivity in RTT. The comparison with resting states aimed to uncover potential biomarkers and insights into the neural processes associated with RTT. Methods and procedures: The study included 15 girls diagnosed with RTT. Throughout sessions lasting about 25 min, participants alternated between active and passive tasks, using an eyetracker device while their brain activity was recorded with a 20-channel EEG. Results revealed significant alterations during cognitive tasks, notably in delta, alpha and beta bands. Both tasks induced spectral pattern changes and connectivity shifts, hinting at enhanced neural processing. Hemispheric asymmetry decreased during tasks, suggesting more balanced neural processing. Linear and nonlinear connectivity alterations were observed in active tasks compared to resting state, while passive tasks showed no significant changes. Conclusions and implications: Results underscores the potential of cognitive stimulation for heightened cognitive abilities, promoting enhanced brain connectivity and information flow in Rett syndrome. These findings offer valuable markers for evaluating cognitive interventions and suggest gaming-related activities as effective tools for improving learning outcomes. Postprint (published version) Àrees temàtiques de la UPC::Ciències de la salut Àrees temàtiques de la UPC::Enginyeria biomèdica Rett syndrome Cognitive stimulation EEG connectivity Attentiontherapeutic intervention Pediatrics EEG connectivity patterns in response to gaming and learning-based cognitive stimulations in Rett syndrome