2026-04-17T06:43:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/3932492026-01-21T10:30:24Zcom_2072_1033col_2072_452950

The relationship between fixation stability and retinal structural parameters in children with anisometropic, strabismic and mixed amblyopia Mompart Martínez, Raquel Argilés Sans, Marc Cardona Torradeflot, Genís Cavero Roig, Lluís González Sanchís, Lluís Pighin, Maria S Àrees temàtiques de la UPC::Ciències de la visió Vision disorders in children Amblyopia DEM Estrabisme Retina -- Diseases Amblyopia Fixation stability Retinal microvasculature Macular thickness Macular volume Stereoacuity Strabismus Anisometropia Trastorns de la visió en els infants Ambliopia Strabismus Retina -- Malalties Background: Amblyopia is an ocular condition leading to structural and functional changes. The relationship between these changes is complex and remains poorly understood. (2) Methods: Participants included 31 children aged 5 to 9 years with strabismic (n = 9), anisometropic (n = 16) and mixed (n = 6) unilateral amblyopia, and 14 age-matched non-amblyopic children. The 95% and 63% Bivariate Contour Ellipse Area (BCEA), axial length, Foveal Avascular Zone (FAZ) area, center macular thickness and volume were assessed. The relationship between these parameters was explored. (3) Results: Statistically significant differences were found among the four groups in best corrected distance visual acuity (BCVA) (p < 0.001), BCEA 95% (p = 0.002) and BCEA 63% (p = 0.002), but not in the FAZ area, central macular thickness, central macular volume and axial length. Eyes with amblyopia had poorer BCVA and larger fixation instability than controls. Inter-ocular differences were more significant in patients with strabismic amblyopia, particularly in BCVA (p = 0.003), central macular thickness (p < 0.001) and central macular volume (p = 0.002). In amblyopic eyes, BCEA 95% and 63% were correlated with BCVA, but not with the FAZ area. (4) Conclusion: Amblyopia is associated with a reduction in fixation stability and BCVA, although there is a general lack of correlation with structural changes, suggesting a complex interaction between anatomy and function in amblyopia. Peer Reviewed Postprint (published version) 2023-07-06 Article https://www.mdpi.com/2075-1729/13/7/1517 http://creativecommons.org/licenses/by/4.0/ Open Access Attribution 4.0 International