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oai:recercat.cat:2117/3863342026-01-18T06:37:01Zcom_2072_1033col_2072_452950

Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices García Mintegui, Claudia Goncharov, Ivan Ortiz Membrado, Laia Jiménez Piqué, Emilio Ginebra Molins, Maria Pau Vedani, Maurizio Cortina Pallás, José Luis Pegueroles Neyra, Marta Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials Universitat Politècnica de Catalunya. Departament d'Enginyeria Química Universitat Politècnica de Catalunya. CIEFMA-PROCOMAME - Disseny Microestructural i Fabricació Avançada de Materials Universitat Politècnica de Catalunya. BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits Universitat Politècnica de Catalunya. R2EM - Resource Recovery and Environmental Management Politecnico di Milano Institut de Bioenginyeria de Catalunya Àrees temàtiques de la UPC::Enginyeria dels materials Biomedical materials Nanotechnology Binary alloys Biomaterials Equal channel angular pressing Nanoindentation Ultrafine-grained materials Zinc alloys Materials biomèdics Nanotecnologia Actual polymeric wound closure devices are not optimal for load-bearing applications due to the low mechanical properties and the risk of inflammation and bacterial infection mainly produced by multifilament and braided configurations. Biodegradable metallic Zn alloys are promising materials candidates; however, mechanical performance, corrosion behaviour, and biological response should be controlled in order to inhibit the risk of inflammation and bacterial infection. To this end, a Zn-2Ag (2 wt% Ag) alloy was processed by ECAP to evaluate the concurrent combined effect of grain refinement and Ag alloying on biodegradation and antibacterial activity. Two ECAP cycles were successfully applied to a Zn-2Ag alloy obtaining a homogeneous ultra-fine-grained structure in which nanoindentation maps suggested isotropic mechanical properties. Lower UTS and YS with higher elongation was reported after ECAP with similar corrosion rates as before processing. ECAP processed samples showed a homogeneous Ag+ release below the minimum inhibitory concentration for S. Aureus and no antibacterial effect was observed by diffusion. As expected, the presence of Ag in Zn-Ag alloys reduced bacterial attachment. Nevertheless, ECAP processed Zn-2Ag provided an excellent antibacterial activity after 3 h probably caused by the uniformly degraded and thus, non– stable, surface observed after bacterial adhesion. Peer Reviewed Postprint (published version) 2023-04-01 Article Garcia, C. [et al.]. Influence of ECAP process on mechanical, corrosion and bacterial properties of Zn-2Ag alloy for wound closure devices. "Materials & design", 1 Abril 2023, vol. 228, núm. article 111817. 1873-4197 https://hdl.handle.net/2117/386334 10.1016/j.matdes.2023.111817 eng https://www.sciencedirect.com/science/article/pii/S0264127523002320 http://creativecommons.org/licenses/by-nc-nd/4.0/ Open Access Attribution-NonCommercial-NoDerivatives 4.0 International application/pdf Elsevier