2026-04-13T18:52:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/3860692026-01-22T04:46:07Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Joseph-Duran, Bernat author Serra-Compte, Albert author Sàrrias, Miquel author Gonzalez, Susana author López Codina, Daniel author Prats Soler, Clara author Català Sabaté, Martí author Álvarez Lacalle, Enrique author Alonso Muñoz, Sergio author Arnaldos, Marina author 2022-09-05 While wastewater-based epidemiology has proven a useful tool for epidemiological surveillance during the COVID-19 pandemic, few quantitative models comparing virus concentrations in wastewater samples and cumulative incidence have been established. In this work, a simple mathematical model relating virus concentration and cumulative incidence for full contagion waves was developed. The model was then used for short-term forecasting and compared to a local linear model. Both scenarios were tested using a dataset composed of samples from 32 wastewater treatment plants and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) incidence data covering the corresponding geographical areas during a 7-month period, including two contagion waves. A population-averaged dataset was also developed to model and predict the incidence over the full geography. Overall, the mathematical model based on wastewater data showed a good correlation with cumulative cases and allowed us to anticipate SARS-CoV-2 incidence in one week, which is of special relevance in situations where the epidemiological monitoring system cannot be fully implemented. The authors want to thank the Catalan Institute for Water Research (Institut Català de Recerca de l’Aigua, ICRA) and the Open Data initiative of the Generalitat de Catalunya for publishing the SARS-CoV-2 concentration and incidence data as open access information. The authors also want to acknowledge the funding of the INNO- 4COV-19 (European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No 101016203) project City Sentinel V-Sense. Peer Reviewed Objectius de Desenvolupament Sostenible::3 - Salut i Benestar Postprint (published version) Àrees temàtiques de la UPC::Ciències de la salut COVID-19 (Disease) Diseases -- Mathematical models Sewage -- Sampling Water -- Sampling Epidemiology Epidemiologia -- Models matemàtics COVID-19 (Malaltia) Aigües residuals--Mostreig Assessing wastewater-based epidemiology for the prediction of SARS-CoV-2 incidence in Catalonia