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oai:recercat.cat:2117/3796602026-01-21T04:38:16Zcom_2072_1033col_2072_452950

Assessing the coupling between local neural activity and global connectivity fluctuations: Application to human intracranial electroencephalography during a cognitive task Vila Vidal, Manel Alkhawaja, Mariam Carreño Martínez, María del Mar Roldan Ramos, Pedro Rumià Arboix, Jordi Donaire Pedraza, Antonio Jesús Deco, Gustavo Tauste Campo, Adrián Francisco Universitat Politècnica de Catalunya. Departament de Física Universitat Politècnica de Catalunya. BIOCOM-SC - Biologia Computacional i Sistemes Complexos Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia Neural transmission Electroencephalography Neurotransmissió Electroencefalografia Cognitive-relevant information is processed by different brain areas that cooperate to eventually produce a response. The relationship between local activity and global brain states during such processes, however, remains for the most part unexplored. To address this question, we designed a simple face-recognition task performed in patients with drug-resistant epilepsy and monitored with intracranial electroencephalography (EEG). Based on our observations, we developed a novel analytical framework (named “local–global” framework) to statistically correlate the brain activity in every recorded gray-matter region with the widespread connectivity fluctuations as proxy to identify concurrent local activations and global brain phenomena that may plausibly reflect a common functional network during cognition. The application of the local–global framework to the data from three subjects showed that similar connectivity fluctuations found across patients were mainly coupled to the local activity of brain areas involved in face information processing. In particular, our findings provide preliminary evidence that the reported global measures might be a novel signature of functional brain activity reorganization when a stimulus is processed in a task context regardless of the specific recorded areas Peer Reviewed Postprint (published version) 2022-01-01 Article Vila, M. [et al.]. Assessing the coupling between local neural activity and global connectivity fluctuations: Application to human intracranial electroencephalography during a cognitive task. "Human Brain Mapping", 2023, vol. 44, núm. 3, p. 1173-1192. 1097-0193 https://hdl.handle.net/2117/379660 10.1002/hbm.26150 eng https://onlinelibrary.wiley.com/doi/10.1002/hbm.26150 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105772GB-I00/ES/TRANSICIONES ENTRE ESTADOS CEREBRALES FORZADAS POR ESTIMULACIONES EXTERNAS EN HUMANOS Y ANIMALES: ESTUDIO BASADO EN MODELOS COMPUTACIONALES/ info:eu-repo/grantAgreement/EC/H2020/945539/EU/Human Brain Project Specific Grant Agreement 3/HBP SGA3 info:eu-repo/grantAgreement/EC/H2020/101017716/EU/Digital twins for model-driven non-invasive electrical brain stimulation/Neurotwin info:eu-repo/grantAgreement/EC/H2020/860563/EU/European School of Network Neuroscience/euSNN 201725.33 http://creativecommons.org/licenses/by-nc-nd/4.0/ Open Access Attribution-NonCommercial-NoDerivatives 4.0 International application/pdf