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00925njm 22002777a 4500 dc Tinajero, Ernesto author Kimmins, Scott D author García-Carvajal, Zaira-Yunuen author Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon author 2021-09 Polymerisation of a-amino acid N-carboxyanhydrides (NCAs) is one of the most common techniques to prepare synthetic polypeptides. Of special interest are the NCAs derived from a-amino acids, L-aspartic acid and L-glutamic acid, since most investigations have been focused on their use to synthesise multiblock copolypeptides or hybrid synthetic polypeptide-polymers to design excipients suitable for delivery of bioactive compounds. This perspective highlights advantages of using L-aspartic acid and L-glutamic over other natural a-amino acids in that their pendant carboxyl group serves as a reactive handle for coupling a variety of reactive groups, and because the resulting polypeptides have the ability to adopt secondary structures. In addition, recent progress in the ring-opening polymerisation of NCAs will be discussed. Throughout, we provide representative examples that shed light on the NCAs polymerisation process, and we finally share our perspectives concerning the practical use of anionic a-amino acids as building blocks for future investigations. Peer Reviewed Objectius de Desenvolupament Sostenible::3 - Salut i Benestar Postprint (published version) Àrees temàtiques de la UPC::Enginyeria química Copolymers Polymerization Drug carriers (Pharmacy) N-carboxyanhydrides Ring-opening polymerisation l-Aspartic acid l-Glutamic acid Synthetic copolypeptides Hybrid copolymers Excipients Bioactive-compounds Copolímers Polimerització Excipients Polypeptide-based materials prepared by ring-opening polymerisation of anionic-based alpha-amino acid N-carboxyanhydrides: A platform for delivery of bioactive-compounds