2026-04-17T03:07:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/3534702026-01-18T08:56:57Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Vidiella, Blai author Guillamon Grabolosa, Antoni author Sardanyes, Josep author Maull Miquel, Víctor author Pla Mauri, Jordi author Conde Pueyo, Núria author Solé, Ricard author 2021-12-01 Complex dynamical fluctuations, from intracellular noise, brain dynamics or computer traffic display bursting dynamics consistent with a critical state between order and disorder. Living close to the critical point has adaptive advantages and it has been conjectured that evolution could select these critical states. Is this the case of living cells? A system can poise itself close to the critical point by means of the so-called self-organized criticality (SOC). In this paper we present an engineered gene network displaying SOC behaviour. This is achieved by exploiting the saturation of the proteolytic degradation machinery in E. coli cells by means of a negative feedback loop that reduces congestion. Our critical motif is built from a two-gene circuit, where SOC can be successfully implemented. The potential implications for both cellular dynamics and behaviour are discussed. Peer Reviewed Postprint (published version) Àrees temàtiques de la UPC::Matemàtiques i estadística::Equacions diferencials i integrals::Sistemes dinàmics Dynamics Linear models (Statistics) Dinàmica Neurones -- Models matemàtics Engineering self-organized criticality in living cells