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00925njm 22002777a 4500 dc Manzo, Carlo author Torreño Piña, Juan Andrés author Joosten, Ben author Reinieren Beeren, Inge author Gualda Manzano, Emilio José author Loza Álvarez, Pablo author Figdor, Carl G. author Garcia-Parajo, Maria F. author Cambi, Alessandra author 2012-11 The C-type lectin DC-SIGN expressed on dendritic cells(DCs) facilitates capture and internalization of a plethora of dif-ferent pathogens. Although it is known that DC-SIGN organizesin nanoclusters at the surface of DCs, the molecular mecha-nisms responsible for this well defined nanopatterning and rolein viral binding remain enigmatic. By combining biochemicaland advanced biophysical techniques, including optical super-resolution and single particle tracking, we demonstrate thatDC-SIGN intrinsic nanoclustering strictly depends on itsmolecular structure. DC-SIGN nanoclusters exhibited free,Brownian diffusion on the cell membrane Postprint (published version) Àrees temàtiques de la UPC::Enginyeria agroalimentària::Ciències de la terra i de la vida::Microbiologia Dendritic Cells. Viral binding Cèl·lules dendrítiques fol·liculars The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells*