2026-04-13T01:44:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/281892026-02-04T03:24:09Zcom_2072_1033col_2072_452950

Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences Cárdenas Domínguez, Martha Ivón Vellido Alcacena, Alfredo Giraldo Arjonilla, Jesús Universitat Politècnica de Catalunya. Departament de Ciències de la Computació Universitat Politècnica de Catalunya. SOCO - Soft Computing Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica Proteomics Bioinformatics Amino acids Biological membranes Molecular biology Proteins G protein coupled receptors Membrane proteins Nonlinear dimensionality reduction Nonlinear mappings Primary amino acid Primary sequences Quantitative estimation Visual interpretation Data visualization Proteòmica Bioinformàtica This brief paper addresses the problem of visually assessing the natural discriminability of the different subtypes that characterize class C G-Protein-Coupled Receptors, which are membrane proteins of interest in pharmacology, from diverse transformations of their primary amino acid sequences. Visualization, achieved using nonlinear dimensionality reduction techniques, is used as an exploratory tool to increase the interpretability of the data subtype structure. Combined with a quantitative estimation of subtype overlapping, this approach should be of help to experts in proteomics. Peer Reviewed Postprint (published version) 2014 Conference report Cárdenas, M.I.; Vellido, A.; Giraldo, J. Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences. A: IEEE-EMBS International Conferences on Biomedical and Health Informatics. "2014 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2014)". Valencia: Institute of Electrical and Electronics Engineers (IEEE), 2014, p. 764-767. 978-147992131-7 https://hdl.handle.net/2117/28189 10.1109/BHI.2014.6864476 eng http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6864476 Restricted access - publisher's policy 4 p. application/pdf Institute of Electrical and Electronics Engineers (IEEE)