2026-04-18T03:28:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1873742025-07-23T03:40:30Zcom_2072_1033col_2072_452951

Tailoring systems pharmacology through computational models De La Maza Prieto, Iñigo Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial Massachusetts Institute of Technology Kolandaivelu, Kumaran Vallverdú Ferrer, Montserrat Àrees temàtiques de la UPC::Informàtica::Automàtica i control Pharmacology Blood--Coagulation Farmacologia Sang -- Coagulació Anticoagulant drugs are essential treatments of cardiovascular diseases like myocardial infarction and stroke, but their effective use requires achieving a careful balance between suppressing pathological clotting (thrombosis) and compromising natural coagulation capabilities (hemostasis). Striking such a balance is difficult given the dynamic network of cellular and molecular reactions that take place in flowing blood. Embracing a systems pharmacology approach, computational and experimental models have been used to map the dynamic response of a novel class of Factor XI inhibitors, and explore their potential as anticoagulant medications with a wide risk/benefit margin. Systems pharmacology, computational model, blood coagulation. Outgoing 2020-05-11 Master thesis https://hdl.handle.net/2117/187374 ETSEIB-240.149360 eng Restricted access - author's decision application/pdf Universitat Politècnica de Catalunya