2026-04-13T04:06:51Zhttps://recercat.cat/oai/requestoai:recercat.cat:2117/1873742025-07-23T03:40:30Zcom_2072_1033col_2072_452951
RECERCAT
author
De La Maza Prieto, Iñigo
2020-05-11
Anticoagulant drugs are essential treatments of cardiovascular diseases like myocardial infarction and stroke, but their effective use requires achieving a careful balance between suppressing pathological clotting (thrombosis) and compromising natural coagulation capabilities (hemostasis). Striking such a balance is difficult given the dynamic network of cellular and molecular reactions that take place in flowing blood. Embracing a systems pharmacology approach, computational and experimental models have been used to map the dynamic response of a novel class of Factor XI inhibitors, and explore their potential as anticoagulant medications with a wide risk/benefit margin. Systems pharmacology, computational model, blood coagulation.Outgoing
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Àrees temàtiques de la UPC::Informàtica::Automàtica i control
Pharmacology
Blood--Coagulation
Farmacologia
Sang -- Coagulació
Tailoring systems pharmacology through computational models
Master thesis