2026-04-17T06:25:38Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1873742025-07-23T03:40:30Zcom_2072_1033col_2072_452951

00925njm 22002777a 4500 dc De La Maza Prieto, Iñigo author 2020-05-11 Anticoagulant drugs are essential treatments of cardiovascular diseases like myocardial infarction and stroke, but their effective use requires achieving a careful balance between suppressing pathological clotting (thrombosis) and compromising natural coagulation capabilities (hemostasis). Striking such a balance is difficult given the dynamic network of cellular and molecular reactions that take place in flowing blood. Embracing a systems pharmacology approach, computational and experimental models have been used to map the dynamic response of a novel class of Factor XI inhibitors, and explore their potential as anticoagulant medications with a wide risk/benefit margin. Systems pharmacology, computational model, blood coagulation. Outgoing Àrees temàtiques de la UPC::Informàtica::Automàtica i control Pharmacology Blood--Coagulation Farmacologia Sang -- Coagulació Tailoring systems pharmacology through computational models