2026-04-13T15:15:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1748932025-07-22T22:47:10Zcom_2072_1033col_2072_452951

Study of macroscopic and microscopic properties of liposomes produced using microfluidic methods Rojo González, Javier Universitat Politècnica de Catalunya. Departament de Física Harvard John A. Paulson School of Engineering and Applied Sciences Weitz, David Pardo Soto, Luis Carlos Àrees temàtiques de la UPC::Física Microfluidics glass capillary devices ultra-thin double emulsions lipid vesicles liposomes phase separation domains symmetrical liposomes asymmetrical liposomes dewetting area compressibility modulus atomic force microscopy osmotic pressure shape deformation. Liposomes For the last decades, lipid vesicles or liposomes, vesicles formed by a bilayer of amphiphilic lipids, have been used as a toy model for studying the cell membrane and for applications in cosmetics and drug delivery. Traditional methods for producing liposomes face some problems such as the heterogeneity in size and composition of the liposomes produced. A few years ago, a novel method that produces liposomes with homogeneous size and composition was developed. This novel method is based on the use of water in oil in water ultra-thin double emulsions, with lipids dissolved in the oil phase, as templates for the liposome production. These ultra-thin double emulsions are produced using glass capillary microfluidic devices. This new method for producing liposomes seems very promising, but since the liposomes are formed by the oil phase evaporation of the double emulsions, the doubt that some residual oil in the bilayer may alter the properties of the liposomes appears. In this work different phenomena and properties of liposomes that have been studied for the ones produced using conventional methods are studied for liposomes produced using microfluidic methods. The microfluidic appr Outgoing 2019-07-15 Bachelor thesis https://hdl.handle.net/2117/174893 PRISMA-144091 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access Attribution-NonCommercial-NoDerivs 3.0 Spain application/pdf east=-71.1170812; north=42.3783003; name=Universitat de Harvard, 29 Oxford St, Cambridge, MA 02138, Estats Units d'Amèrica Universitat Politècnica de Catalunya