2026-04-13T06:59:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/165042026-02-01T08:06:57Zcom_2072_1033col_2072_452950

Preparation of biodegradable polylactide microparticles via a biocompatible procedure Levato, R. Mateos Timoneda, Miguel Ángel Planell Estany, Josep Anton Àrees temàtiques de la UPC::Enginyeria dels materials Biomedical materials Biocompatibility Biodegradable Green solvents Microparticles Poly(lactic acid) Biomaterials PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 mm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques. Peer Reviewed Postprint (published version) 2012-04 Article http://onlinelibrary.wiley.com/doi/10.1002/mabi.201100383/pdf http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Restricted access - publisher's policy Attribution-NonCommercial-NoDerivs 3.0 Spain