2026-04-13T14:57:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/165042026-02-01T08:06:57Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Levato, R. author Mateos Timoneda, Miguel Ángel author Planell Estany, Josep Anton author 2012-04 PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 mm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques. Peer Reviewed Postprint (published version) Àrees temàtiques de la UPC::Enginyeria dels materials Biomedical materials Biocompatibility Biodegradable Green solvents Microparticles Poly(lactic acid) Biomaterials Preparation of biodegradable polylactide microparticles via a biocompatible procedure