2026-04-05T12:43:19Zhttps://recercat.cat/oai/requestoai:recercat.cat:2117/149072026-02-04T07:22:26Zcom_2072_1033col_2072_452950
RECERCAT
author
Kedzierska, A.M.
author
Drton, M.
author
Guigó, Roderic
author
Casanellas Rius, Marta
2011-10
In phylogenetic inference, an evolutionarymodel describes the substitution processes along each edge of a phylogenetic tree.
Misspecification of the model has important implications for the analysis of phylogenetic data. Conventionally, however, the
selection of a suitable evolutionary model is based on heuristics or relies on the choice of an approximate input tree. We
introduce a method for model Selection in Phylogenetics based on linear INvariants (SPIn), which uses recent insights on
linear invariants to characterize a model of nucleotide evolution for phylogenetic mixtures on any number of components.
Linear invariants are constraints among the joint probabilities of the bases in the operational taxonomic units that hold
irrespective of the tree topologies appearing in the mixtures. SPIn therefore requires no input tree and is designed to deal
with nonhomogeneous phylogenetic data consisting ofmultiple sequence alignments showing different patterns of evolution,
for example, concatenated genes, exons, and/or introns. Here, we report on the results of the proposedmethod evaluated on
multiple sequence alignments simulatedunder a variety of single-tree andmixture settings for both continuous- and discretetime
models. In the simulations, SPInsuccessfully recovers the underlying evolutionarymodel and is shown to performbetter
than existing approaches.Peer ReviewedPostprint (published version)
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Restricted access - publisher's policy Attribution-NonCommercial-NoDerivs 3.0 Spain
Phylogeny
Sistemes lineals
Filogènia
SPIn: model selection for phylogenetic mixtures via linear invariants
Article