2026-04-17T11:33:57Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1315782026-01-30T01:54:43Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Forns, Joan author Pottegard, Anton author Reinders, Tammo author Poblador Plou, Beatriz author Morros Padrós, Rosa author Brandt, Lena author Cainzos Achirica, Miguel author Hellfritzsch, M author Schink, Tania author Prados Torres, Alexandra author Giner Soriano, Maria author Hagg, David author Hallas, Jesper author Cortés Martínez, Jordi author Jacquot, Emmanuelle author Deltour, Nicole author Pérez Gutthann, Susana author Pladevall, Miquel author Reutfors, Johan author 2019-04-15 Background We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients. Peer Reviewed Postprint (author's final draft) Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències Sampling (Statistics) Biology Antidepressants Comorbidity Drug utilization study Europe Mostreig (Estadística) Biologia Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of antidepressant initiators