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oai:recercat.cat:2117/1219002026-02-07T07:43:52Zcom_2072_1033col_2072_452950

Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry Gálvez Montón, Carolina Arauz Garofalo, Gianluca Rodríguez Leor, Oriol Soler Botija, Carolina Amorós García de Valdecasas, Susana Bayés Genis, Antoni O'Callaghan Castellà, Juan Manuel Macià Bros, Ferran Tejada Palacios, Javier Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones Àrees temàtiques de la UPC::Física::Física molecular::Espectroscòpia molecular Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia Microwave spectroscopy Cardiology Espectroscòpia de microones Cardiologia Some conditions are well known to be directly associated with stent failure, including in-stent re-occlusion and stent fracture. Currently, identification of these high-risk conditions requires invasive and complex procedures. This study aims to assess microwave spectrometry (MWS) for monitoring stents non-invasively. Preliminary ex vivo data are presented to move to in vivo validation. Fifteen mice were assigned to receive subcutaneous stent implantations (n¿=¿10) or sham operations (n¿=¿5). MWS measurements were carried out at 0, 2, 4, 7, 14, 22, and 29 days of follow-up. Additionally, 5 stented animals were summited to micro-CT analyses at the same time points. At 29 days, 3 animals were included into a stent fracture subgroup and underwent a last MWS and micro-CT analysis. MWS was able to identify stent position and in-stent stenosis over time, also discerning significant differences from baseline measures (P¿<¿0.001). Moreover, MWS identified fractured vs. non-fractured stents in vivo. Taken together, MWS emerges as a non-invasive, non-ionizing alternative for stent monitoring. MWS analysis clearly distinguished between in-stent stenosis and stent fracture phenomena. Peer Reviewed Postprint (published version) 2018-10-04 Article Gálvez, C., Arauz-Garofalo, G., Rodríguez-Leor, O., Soler, C., Amorós, S., Bayés-Genis, A., O'callaghan, J., Macià, F., Tejada, J. Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry. "Scientific reports", 4 Octubre 2018, núm. 8, p. 1-8. 2045-2322 https://hdl.handle.net/2117/121900 10.1038/s41598-018-33254-9 eng https://www.nature.com/articles/s41598-018-33254-9 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access Attribution-NonCommercial-NoDerivs 3.0 Spain 8 p. application/pdf Nature