2026-04-17T15:44:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1192242026-01-30T07:38:42Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Fabregat Jové, Georgina author Giménez, Alessia author Díaz Andrade, Angélica María author Puiggalí Bellalta, Jordi author Alemán Llansó, Carlos author 2018-01-01 "This is the pre-peer reviewed version of the following article: G. Fabregat, A. Giménez, A. Díaz, J. Puiggalí, C. Alemán, Macromol. Biosci. 2018, 18, 1800014 , which has been published in final form at https://doi.org/10.1002/mabi.201800014 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." A dual-functional device is fabricated to release progressively dopamine (DA) from a biohydrogel under real-time monitoring via electrochemical detection. For this purpose, a poly-¿-glutamic acid biohydrogel is assembled with a poly(3,4-ethylenedioxythiophene) (PEDOT) layer, previously deposited onto a screen printed electrode. The biohydrogel is formulated to achieve dimensional stability and maximum DA-loading capacity. Conditions for DA-loading are influenced by the oxidation of the neurotransmitter in acid environments and the poor resistance of PEDOT to the lyophilization. The performance of the device is proved in a medium with the physiological pH of blood and the cerebrospinal fluid. The progressive release of DA is successfully monitored by the device, the limit of detection and sensitivity of the integrated sensor being 450 × 10-9m and 8 × 10-5 mA µm-1, respectively. The effect of electrochemical stimulation in the kinetics of the DA release is also investigated applying potential ramps in cyclic phase to alter the biohydrogel morphology. Peer Reviewed Postprint (author's final draft) Àrees temàtiques de la UPC::Enginyeria química Biochemical engineering Dopamine Polymers Bioquímica Polímers Dual-functionalization device for therapy through dopamine release and monitoring