2026-04-17T09:28:17Zhttps://recercat.cat/oai/request
oai:recercat.cat:2117/1176912026-01-22T04:34:09Zcom_2072_1033col_2072_452950
RECERCAT author Merino, Anna author Puigví, Laura author Boldú, L. author Alférez Baquero, Edwin Santiago author Rodellar Benedé, José 2018-05-09 Introduction Morphological review of the peripheral blood smear is still a crucial diagnostic aid as it provides relevant information related to the diagnosis and is important for selection of additional techniques. Nevertheless, the distinctive cytological characteristics of the blood cells are subjective and influenced by the reviewer's interpretation and, because of that, translating subjective morphological examination into objective parameters is a challenge. Methods The use of digital microscopy systems has been extended in the clinical laboratories. As automatic analyzers have some limitations for abnormal or neoplastic cell detection, it is interesting to identify quantitative features through digital image analysis for morphological characteristics of different cells. Result Three main classes of features are used as follows: geometric, color, and texture. Geometric parameters (nucleus/cytoplasmic ratio, cellular area, nucleus perimeter, cytoplasmic profile, RBC proximity, and others) are familiar to pathologists, as they are related to the visual cell patterns. Different color spaces can be used to investigate the rich amount of information that color may offer to describe abnormal lymphoid or blast cells. Texture is related to spatial patterns of color or intensities, which can be visually detected and quantitatively represented using statistical tools. Conclusion This study reviews current and new quantitative features, which can contribute to optimize morphology through blood cell digital image processing techniques.Peer ReviewedPostprint (published version) Open Access Àrees temàtiques de la UPC::Enginyeria biomèdica Blood Leukemia Lymphomas Morphology Sang Leucèmia Morfologia Optimizing morphology through blood cell image analysis Article