2026-04-05T10:46:23Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1066652026-01-27T03:40:00Zcom_2072_1033col_2072_452950

Experimental and topological determination of the pressure-temperature phase diagram of morniflumate, a pharmaceutical ingredient with anti-inflammatory properties Barrio Casado, María del Tamarit Mur, José Luis Céolin, René Robert, Benoit Guechot, C. Teulon, J.M. Rietveld, Ivo B. Àrees temàtiques de la UPC::Física::Termodinàmica Thermodynamics High-pressure Pressure-temperature phase diagram Clapeyron Topological phase diagram Specific volume Density Termodinàmica The pressure-temperature phase diagram of morniflumate (niflumic acid ß-morpholinoethyl ester) has been obtained by high-pressure thermal analysis. In addition, calorimetric melting data (TI¿L = (348.1 ± 0.4) K and ¿HI¿L = (89 ± 2) J·g-1) and the specific volumes of the solid and the liquid state have been obtained under normal pressure. Comparison of the measured high-pressure melting data with the equilibrium curve obtained through the Clapeyron equation indicates that the initial slopes are the same (dP/dT = (2.96 ± 0.06) MPa·K-1) at the melting point under normal pressure. The fact that the Clapeyron equation can be used to construct topological phase diagrams may be of interest for the food and pharmaceutical industries. Peer Reviewed Postprint (author's final draft) 2017-09-01 Article http://www.sciencedirect.com/science/article/pii/S0021961417301544 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ Open Access Attribution-NonCommercial-NoDerivs 3.0 Spain