2026-04-13T01:59:10Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1024382026-01-27T02:53:33Zcom_2072_1033col_2072_452950

00925njm 22002777a 4500 dc Sáez Viñas, Pablo author Malve, M. author Martínez, M.A. author 2015-08 Endothelial cells are key units in the regulatory biological process of blood vessels. They represent an interface to transmit variations on the fluid dynamic changes. They are able to adapt its cytoskeleton, by means of microtubules reorientation and F-actin reorganization, due to new mechanical environments. Moreover, they are responsible for initiating a huge cascade of biological processes, such as the release of endothelins (ET-1), in charge of the constriction of the vessel and growth factors such as TGF-ß and PDGF. Although a huge efforts have been made in the experimental characterization and description of these two issues the computational modeling has not gained such an attention. In this work we study the 3D remodeling of endothelial cells based on the main features of blood flow. In particular we study how different oscillatory shear index and the time average wall shear stresses modify the endothelial cell shape. We found our model fitted the experimental works presented before in in vitro studies. We also include our model within a computational fluid dynamics simulation of a carotid artery to evaluate endothelial cell shape index which is a key predictor of atheroma plaque formation. Moreover, our approach can be coupled with models of collagen and smooth muscle cell growth, where remodeling and the associated release of chemical substance are involved. Peer Reviewed Postprint (author's final draft) Àrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat Àrees temàtiques de la UPC::Matemàtiques i estadística::Investigació operativa::Simulació Combinatorial probabilities Numerical analysis--Simulation methods Endothelial cells Remodeling CFD Probabilitats Anàlisi numèrica Classificació AMS::60 Probability theory and stochastic processes::60C05 Combinatorial probability Classificació AMS::65 Numerical analysis::65C Probabilistic methods, simulation and stochastic differential equations A theoretical model of the endothelial cell morphology due to different waveforms