2026-04-13T04:13:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:2117/1019762026-01-30T09:04:54Zcom_2072_1033col_2072_452950

Colonic content: effect of diet, meals, and defecation Bendezú García, Álvaro Mego, Marianela Monclús Lahoya, Eva Merino, Xavi Accarino Garaventa, Anna María Malagelada Benapres, Juan Ramon Navazo Álvaro, Isabel Azpiroz Vidaur, Fernando Universitat Politècnica de Catalunya. Departament de Ciències de la Computació Universitat Politècnica de Catalunya. ViRVIG - Grup de Recerca en Visualització, Realitat Virtual i Interacció Gràfica Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Diagnòstic per la imatge Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica Abdomen-Magnetic resonance imaging Gastrointestinal gas Intestines--Microbiology Defecation colonic content diet fecal output intestinal gas meals Abdomen-Imatges per ressonància magnètica Gasos gastrointestinals Intestins--Microbiologia Defecació This is the peer reviewed version of the following article: Bendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F. Colonic content: effect of diet, meals, and defecation. "Neurogastroenterology and motility", Febrer 2017, vol. 29, núm. 2, which has been published in final form at [http://onlinelibrary.wiley.com.recursos.biblioteca.upc.edu/doi/10.1111/nmo.12930/full]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The metabolic activity of colonic microbiota is influenced by diet; however, the relationship between metabolism and colonic content is not known. Our aim was to determine the effect of meals, defecation, and diet on colonic content. Methods: In 10 healthy subjects, two abdominal MRI scans were acquired during fasting, 1 week apart, and after 3 days on low- and high-residue diets, respectively. With each diet, daily fecal output and the number of daytime anal gas evacuations were measured. On the first study day, a second scan was acquired 4 hours after a test meal (n=6) or after 4 hours with nil ingestion (n=4). On the second study day, a scan was also acquired after a spontaneous bowel movement. Results: On the low-residue diet, daily fecal volume averaged 145 ± 15 mL; subjects passed 10.6 ± 1.6 daytime anal gas evacuations and, by the third day, non-gaseous colonic content was 479 ± 36 mL. The high-residue diet increased the three parameters to 16.5 ± 2.9 anal gas evacuations, 223 ± 19 mL fecal output, and 616 ± 55 mL non-gaseous colonic content (P<.05 vs low-residue diet for all). On the low-residue diet, non-gaseous content in the right colon had increased by 41 ± 11 mL, 4 hours after the test meal, whereas no significant change was observed after 4-hour fast (-15 ± 8 mL; P=.006 vs fed). Defecation significantly reduced the non-gaseous content in distal colonic segments. Conclusion & inferences: Colonic content exhibits physiologic variations with an approximate 1/3 daily turnover produced by meals and defecation, superimposed over diet-related day-to-day variations. Peer Reviewed Postprint (author's final draft) 2017-01-29 Article Bendezú, Á., Mego, M., Monclús, E., Merino, X., Accarino, A., Malagelada, J., Navazo, I., Azpiroz, F. Colonic content: effect of diet, meals, and defecation. "Neurogastroenterology and motility", Febrer 2017, vol. 29, núm. 2. 1350-1925 https://hdl.handle.net/2117/101976 10.1111/nmo.12930 eng Open Access application/pdf