2026-04-18T02:06:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/5370742024-12-23T14:52:57Zcom_2072_352787com_2072_351515com_2072_1741col_2072_352789

Sensitization to avian and fungal proteins in diferent work environments Sánchez-Díez, Silvia Muñoz, Xavier Montalvo, Tomás Ojanguren, Iñigo Romero-Mesones, Christian Senar, Juan Carlos Peracho-Tobeña, Victor Cruz, María-Jesús Immunoglobulines Pneumònia Malalties infeccioses en els animals Zoonosi 59 Introduction Hypersensitivity pneumonitis (HP) is usually caused by the inhalation of avian and fungal proteins. The present study assesses a cohort of Urban Pest Surveillance and Control Service (UPSCS) workers with high exposure to avian and fungal antigens, in order to identify their degree of sensitization and the potential risk of developing HP. Methods Workers were divided according to their work activity into Nest pruners (Group 1) and Others (Group 2). All individuals underwent a medical interview, pulmonary function tests and the determination of specifc IgG antibodies. Antigenic proteins of pigeon sera were analysed using two-dimensional immunoblotting. Proteins of interest were sequenced by liquid-chromatography–mass spectrometry (LC–MS). Results 101 workers were recruited (76 men, average age: 42 yrs); (Group 1=41, Group 2=60). Up to 30% of the study population exhibited increased levels of IgGs to pigeon, small parrot and parrot, and up to 60% showed high levels of Aspergillus and Penicillium IgGs. In Group 1, specifc parakeet and Mucor IgGs were higher (p=0.044 and 0.003 respectively) while DLCO/VA% were lower (p=0.008) than in Group 2. Two-dimensional immunoblotting showed protein bands of 20–30 KDa recognized by HP patients but not by workers. LC–MS analysis identifed Ig Lambda chain and Apolipoprotein A-I as candidate proteins for distinguishing HP patients from exposed workers. Conclusions Two pigeon proteins were identifed that may play a role in the development of pathological diferences between HP patients and exposed workers. DLCO/VA may have a predictive value in the development of HP disease 2023-11-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://hdl.handle.net/2072/537074 https://doi.org/10.1186/s13223-023-00852-w eng Allergy, asthma & clinical immunology, Vol. 19, Art. 96 (2023), 9 p. L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/openAccess 9 p. application/pdf RECERCAT (Dipòsit de la Recerca de Catalunya)