2026-04-17T18:54:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/5223052024-12-20T15:41:30Zcom_2072_300912com_2072_4427col_2072_301309

Photochemical organocatalytic enantioselective radical γ-functionalization of α-branched enals Balletti, Matteo Marcantonio, Enrico Melchiorre, Paolo Reported herein is a rare example of asymmetric catalytic functionalisation of enals at the remote γ-position, proceeding via a radical path. The process requires visible light and exploits the synergistic actions of two distinct organocatalysts. A nucleophilic organic catalyst generates radicals upon SN2-based activation of commercially available alkyl halides and blue light irradiation. Concomitantly, a chiral secondary amine catalyst triggers the formation of a dienamine from α-branched enals. This chiral dienamine intercepts the photogenerated radicals with excellent γ- selectivity and good sterecontrol. 2023-04-21T02:45:06Z 2024-04-23T10:54:37Z 2023-04-21T02:45:06Z 2024-04-23T10:54:37Z 2023-04-21T02:45:06Z 2024-04-23T10:54:37Z 2022-04-21 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion http://hdl.handle.net/2072/522305 https://doi.org/10.1039/D2CC01638A eng Agencia Estatal de Investigación (PID2019- 106278GB-I00) MCIN/AEI/10.13039/ 501100011033 (CEX2019- 000925-S) info:eu-repo/semantics/openAccess You have selected the Attribution-NonCommercial-NoDerivatives 4.0 International License. This license is permanently located at http://creativecommons.org/licenses/by-nc-nd/4.0/. RECERCAT (Dipòsit de la Recerca de Catalunya)