2026-04-17T18:02:29Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/5223052024-12-20T15:41:30Zcom_2072_300912com_2072_4427col_2072_301309

00925njm 22002777a 4500 dc Balletti, Matteo author Marcantonio, Enrico author Melchiorre, Paolo author 2022-04-21 Reported herein is a rare example of asymmetric catalytic functionalisation of enals at the remote γ-position, proceeding via a radical path. The process requires visible light and exploits the synergistic actions of two distinct organocatalysts. A nucleophilic organic catalyst generates radicals upon SN2-based activation of commercially available alkyl halides and blue light irradiation. Concomitantly, a chiral secondary amine catalyst triggers the formation of a dienamine from α-branched enals. This chiral dienamine intercepts the photogenerated radicals with excellent γ- selectivity and good sterecontrol. http://hdl.handle.net/2072/522305 https://doi.org/10.1039/D2CC01638A Photochemical organocatalytic enantioselective radical γ-functionalization of α-branched enals