2026-04-13T06:48:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4875512025-10-07T15:44:36Zcom_2072_98col_2072_378192

Update on the Symptomatic Treatment of Huntington's Disease : From Pathophysiology to Clinical Practice Olmedo-Saura, Gonzalo Bernardi, Eugenio Bojtos, Lidia Martínez-Horta, Saul Pagonabarraga Mora, Javier Kulisevsky, Jaime Pérez-Pérez, Jesús Huntington disease Chorea Movement disorders Cognitive dysfunction Psychiatric symptoms Pathophysiology Huntington's disease (HD) is the most common autosomal dominant neurodegenerative disorder, characterized by a triad of motor dysfunction, cognitive decline, and psychiatric disturbances. While recent efforts have focused on developing disease-modifying therapies, no treatment has yet demonstrated clinical efficacy. As a result, symptomatic treatment remains the cornerstone of care. However, high-quality evidence from large randomized trials is limited, and therapeutic decisions must rely on clinical expertise and extrapolation from other neurological or psychiatric conditions. This narrative review provides a comprehensive and practical overview of symptomatic treatment strategies for HD with emphasis on the pathophysiological underpinnings of each symptom and the molecular mechanisms of available and emerging therapies, aiming to support rational, individualized management. Finally, we highlight the critical role of non-pharmacological interventions and the need for multidisciplinary approaches to optimize patient outcomes and quality of life. 2025 Article de revisió https://ddd.uab.cat/record/319599 urn:10.3390/ijms26136220 urn:oai:ddd.uab.cat:319599 urn:scopus_id:105010295971 urn:articleid:14220067v26n13p6220 urn:oai:pubmedcentral.nih.gov:12250415 urn:pmid:40650011 urn:pmc-uid:12250415 urn:pmcid:PMC12250415 urn:oai:egreta.uab.cat:publications/44728e48-ccb5-41ba-8fb9-ec7e666e69f4 http://hdl.handle.net/2072/487551 eng Instituto de Salud Carlos III CM24/00023 International journal of molecular sciences ; Vol. 26 Núm. 13 (July 2025), p. 6220 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf