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Trait impulsivity and cognitive domains involving impulsivity and compulsivity as predictors of gambling disorder treatment response Mallorquí-Bagué, Núria Mestre-Bach, Gemma Lozano Madrid, María Fernández Aranda, Fernando Granero, Roser Vintró Alcaraz, Cristina Del Pino Gutiérrez, Amparo Steward, Trevor Gomez-Peña, Monica Aymamí, Neus Mena Moreno, Teresa Menchón Magriñá, José Manuel Jiménez-Murcia, Susana Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut Cognitive flexibility Compulsivity Gambling disorder Impulsivity Inhibitory control Treatment Gambling disorder (GD) is a highly heterogeneous condition with high rates of chronicity, relapses and treatment dropout. The aim of this study was to longitudinally explore the associations between trait impulsivity, impulsivity-compulsivity related cognitive domains, and treatment outcome in an outpatient sample of adult patients with GD. Methods: 144 adult male participants diagnosed with GD undergoing cognitive-behavioural treatment (CBT) at a specialized outpatient service completed a series of neuropsychological tests to assess executive functioning (including cognitive flexibility, inhibition control and decision making) and psychometric questionnaires. Results: Trait impulsivity predicted low compliance [UPPS-P negative urgency (B = 0.113; p = 0.019)] and relapse [UPPS-P negative urgency (B = 0.140; p = 0.015)] at 5 weeks of treatment and dropout at the end of treatment [(UPPS-P sensation seeking B = 0.056; p = 0.045)]. Cognitive flexibility performance predicted: dropout rates at the end of treatment [WCST perseverative errors (B = 0.043; p = 0.042)]; dropout [WCST categories completed (B = -1.827; p = 0.020)] and low compliance or relapses at follow-up [WCST perseverative errors (B = 0.128; p = 0.020)]; and time to first relapse [WCST failure to maintain set (B = -0.374; p = 0.048)] and time to dropout [WCST perseverative errors (B = 0.0198; p = 0.019)]. Conclusions: Our findings indicate impulsivity-compulsivity levels may influence response to GD treatment (i.e.: low compliance and dropout or relapse rates) thus representing a potential target for improving treatment outcomes. 2018 Article https://ddd.uab.cat/record/319809 urn:10.1016/j.addbeh.2018.07.006 urn:oai:ddd.uab.cat:319809 urn:oai:egreta.uab.cat:publications/f89a3d1f-0e0f-411f-8d71-a1c59960f5a3 urn:pure_id:33019395 urn:recercauab:85050212686 urn:scopus_id:85050212686 urn:pmid:30048796 urn:articleid:18736327v87p169 eng Addictive behaviors ; Vol. 87 (2018), p. 169-176 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. https://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf