2026-04-17T14:41:09Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4862572025-08-31T18:30:40Zcom_2072_98col_2072_378192

Platelet miRNA Biosignature Discriminates between Dementia with Lewy Bodies and Alzheimer's Disease Gámez-Valero, Ana Campdelacreu, Jaume Vilas, Dolores Ispierto, Lourdes Gascon-Bayarri, Jordi Reñé, Ramón Álvarez, Ramiro Armengol, Maria P. Borràs i Serres, Francesc Enric Beyer, Katrin Alzheimer disease Dementia with Lewy bodies Mirna Peripheral biomarkers Platelets Synucleinopathies Dementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia, after Alzheimer's disease (AD), and presents pathological and clinical overlap with both AD and Parkinson's disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets, previously related to neurodegeneration, contain microRNAs (miRNAs) whose analysis may provide disease biomarkers. Here, we profiled the whole platelet miRNA transcriptome from DLB patients and healthy controls. Differentially expressed miRNAs were further validated in three consecutive studies from 2017 to 2019 enrolling 162 individuals, including DLB, AD, and PD patients, and healthy controls. Results comprised a seven-miRNA biosignature, showing the highest diagnostic potential for the differentiation between DLB and AD. Additionally, compared to controls, two miRNAs were down-regulated in DLB, four miRNAs were up-regulated in AD, and two miRNAs were down-regulated in PD. Predictive target analysis identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation. Our cross-sectional study assesses the identification of a novel, highly specific and sensitive platelet-associated miRNA-based biosignature, which distinguishes DLB from AD. 2021 Article https://ddd.uab.cat/record/315609 urn:10.3390/biomedicines9091272 urn:oai:ddd.uab.cat:315609 urn:pmcid:PMC8466211 urn:pmc-uid:8466211 urn:pmid:34572457 urn:oai:pubmedcentral.nih.gov:8466211 urn:oai:egreta.uab.cat:publications/ea5c5cdd-1759-45f8-bc14-64562839363b http://hdl.handle.net/2072/486257 eng Ministerio de Economía y Competitividad PI15/00216 Instituto de Salud Carlos III PI18/00276 Biomedicines ; Vol. 9 (september 2021) open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ application/pdf