2026-04-13T06:55:12Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4849702025-10-17T17:56:32Zcom_2072_98col_2072_378192

The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii Gaona Soler, Marc Corral, Jordi Campoy Sánchez, Susana Barbé García, Jordi Pérez-Varela, María Aranda Rodríguez, Jesús Acinetobacter MFS efflux pump LysR-type transcriptional regulator Co-trimoxazole Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence. 2024 Article Agencia Estatal de Investigación PID2020-117708GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00646 Agència de Gestió d'Ajuts Universitaris i de Recerca 2023/PROD-00011 Antimicrobial Agents and Chemotherapy ; Vol. 68, Issue 10 (October 2024), art. e00712-24 open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/