2026-04-17T02:16:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4849702025-10-17T17:56:32Zcom_2072_98col_2072_378192

00925njm 22002777a 4500 dc Gaona Soler, Marc author Corral, Jordi author Campoy Sánchez, Susana author Barbé García, Jordi author Pérez-Varela, María author Aranda Rodríguez, Jesús author 2024 Acinetobacter baumannii is a notorious opportunistic pathogen responsible for healthcare-associated infections worldwide. Efflux pumps play crucial roles in mediating antimicrobial resistance, motility, and virulence. In this study, we present the identification and characterization of the new A. baumannii efflux pump SxtP belonging to the MFS superfamily (major facilitator superfamily), along with its associated activator LysR-type transcriptional regulator (LTTR) SxtR, demonstrating their roles in sulfamethoxazole/trimethoprim (also known as co-trimoxazole or SXT) resistance, surface-associated motility and virulence. Acinetobacter MFS efflux pump LysR-type transcriptional regulator Co-trimoxazole The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of Acinetobacter baumannii