2026-04-17T17:28:18Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4841442025-10-05T14:07:29Zcom_2072_98col_2072_378192

Antibiotic desensitization as a potential tool in antimicrobial stewardship programs : retrospective data analysis and systematic literature review Rodríguez-Alarcón, Alicia Barceló-Vidal, Jaime Echeverría-Esnal, Daniel Sorlí, Luisa Güerri-Fernández, Roberto Ramis Fernández, Sofía Martina Benítez-Cano, Adela Sendra, Elena López Montesinos, Inmaculada Membrilla-Fernández, Estela Ferrández, Olivia Adàlia Bartolomé, Ramon Horcajada, Juan Pablo Escolano Villen, Fernando Gómez-Zorrilla, Silvia Grau, Santiago Anti-bacterial agents Antimicrobial stewardship programs Desensitization Hypersensitivity Immunologic Penicillins Objectives: Antibiotic allergy labels (AAL) are related to worse therapeutic results. Strategies to improve the management of these patients, such as the implementation of antibiotic desensitization, are essential for Antimicrobial Stewardship Programs (ASP). The aim of our study is to evaluate the efficacy and safety of antibiotic desensitization procedures for the management of patients with AAL. Methods: A retrospective study from 2015 to 2022 was performed to describe all antibiotic desensitization conducted in our institution, within the framework of ASP. A systematic literature review using electronic databases, such as PubMed, was also done to identify studies describing antibiotic desensitization between 2000 and 2022. Results: Sixteen antibiotic desensitization protocols were carried out in our institution. In fourteen cases, the desensitization was successfully completed, and the antibiotic could be used to treat the infection. In the systematic review, twenty-two studies were included, with a total of 202 desensitization episodes. In 97% of them, the desensitization was completed successfully. No desensitization-related mortality was observed neither in our cohort nor in literature review. Conclusions: Antibiotic desensitization strategies should be considered a safe and effective tool that can be included in ASP for patients with a high risk of or confirmed allergy to penicillin. 2022 Article Instituto de Salud Carlos III PI21/00509 Expert Review of Anti-Infective Therapy ; Vol. 20, Núm. 11 (November 2022), p. 1491-1500 open access Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets. https://rightsstatements.org/vocab/InC/1.0/