2026-04-17T15:55:22Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4827732025-04-03T12:07:20Zcom_2072_98col_2072_378192

Synergistic role of nanoceria on the ability of tobacco smoke to induce carcinogenic hallmarks in lung epithelial cells Rubio Lorente, Laura Bach Griera, Jordi Marcos Dauder, Ricardo Hernández Bonilla, Alba CeO2NP Cell transformation Cigarette smoke condensate co-exposure Lung BEAS-2B cells Nanoceria in vitro long-term exposure Aim: Since controversial results have been obtained in studies dealing with nanoceria usefulness in biomedical applications, the transforming effects of long-term exposure to nanoceria in lung epithelial cells, alone or together with cigarette smoke condensate (CSC), were evaluated. Materials & methods: In vitro cell transformation techniques were used to study several hallmarks of carcinogenesis. Morphology, cell proliferation, gene expression, cell migration, anchorage-independent cell growth and cell secretome were analyzed. Results & conclusion: Data evidence no transforming ability of nanoceria, but support a synergistic role on CSC's transforming ability. A more noticeable spindle-like phenotype, increased proliferation rate, higher degree of differentiation status dysregulation, higher migration capacity, increased anchorage-independent cell growth and higher levels of MMP-9 and cell growth promoting capability, were observed. In addition, nanoceria co-exposure exacerbates the expression of FRA-1. 2017 Article https://ddd.uab.cat/record/308393 urn:10.2217/nnm-2017-0205 urn:oai:ddd.uab.cat:308393 urn:oai:egreta.uab.cat:publications/26916cab-b635-4c3b-b175-68d81fa6d6f6 urn:pure_id:34144342 urn:recercauab:85034447596 urn:scopus_id:85034447596 urn:wos_id:000417039300004 urn:pmid:29094638 urn:articleid:17486963v12n23p2623 http://hdl.handle.net/2072/482773 eng European Commission 310584 Agencia Estatal de Investigación BFU2016-76831-R Nanomedicine ; Vol. 12, issue 23 (December 2017), p. 2623-2635 open access Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets. https://rightsstatements.org/vocab/InC/1.0/ application/pdf