2026-04-13T01:01:37Zhttps://recercat.cat/oai/request
oai:recercat.cat:2072/4826082025-04-03T11:48:00Zcom_2072_98col_2072_378192
RECERCAT author Codes-Méndez, Helena author Jeria-Navarro, Sicylle author Park, Hye S author Moya, Patricia author Magallares López, Berta Paula author Moltó, Elisabeth author Álvaro, Yolanda author Mariscal, Anaís author Moga, Esther author Tandaipan, Jose Luis author Díaz Torne, César author Laiz, Ana author Sainz, Luis author Castellvi, Ivan author Corominas, Hèctor 2025-04-03T11:48:00Z 2025-04-03T11:48:00Z 2024 http://hdl.handle.net/2072/482608 Objectives : Cryoglobulinemia (CG) is marked by abnormal immunoglobulins (Ig) in serum, precipitating at temperatures below 37 °C. Current classification categorizes CG into three subtypes (types I, II, and III) based on Ig clonality. The features distinguishing patients with CG based on their etiology remain unidentified. Aiming to characterize clinical and serological profiles of CG individuals, we conducted an observational analysis of a large cohort of patients and compared their characteristics based on underlying causes: hepatovirus (HV) infections, rheumatic diseases (RD), hematological disorders, and unidentified etiology (essential CG). Methods : We analyzed 252 cryoglobulin-positive serum samples from 182 patients and classified these into the four etiological groups. A separate sub-analysis was carried out for 10 patients meeting criteria for multiple diseases. We collected demographic, clinical, and laboratory data: CG characterization, complement (C3 and C4) levels, antinuclear antibodies (ANA), and rheumatoid factor (RF). Kruskal-Wallis and Wilcoxon-Mann-Whitney U- tests were used for comparisons. Results : Most patients (93.3%) had mixed cryoglobulinemia (types II + III), with 6.7% having type I. HV infection, predominantly hepatitis C, was the main (52.9%) associated condition within the cohort, followed by rheumatic (27.3%) and hematological (9.8%) disorders. In our cohort, ANA were frequent (45.3%) and often associated with RF positivity (43.6%) and decreased complement levels (C3: 42.4%, C4: 32.5%). Essential CG and CG associated with RD had a higher prevalence of cutaneous manifestations (p < 0.01) and renal involvement (p = 0.017). Hematological disorder-related CG showed higher cryoglobulin and RF concentrations (p < 0.01), despite milder symptoms. Conclusions : Our study underscores a mixed prevalence of CG across disease subgroups, with hepatitis-C virus as the primary factor, followed by rheumatic and hematological disorders. Four clinical and serological profiles of CG were identified based on their etiologies. open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0/ Cryoglobulinemia Vasculitis Hepatitis C Rheumatic disease Hematological disease Clinical and Serological Profiles in Cryoglobulinemia : Analysis of Isotypes and Etiologies Article