2026-04-13T01:40:49Zhttps://recercat.cat/oai/request

oai:recercat.cat:2072/4813532025-05-08T16:31:05Zcom_2072_98col_2072_378192

urn:hdl:2072/481353 Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans Valle, Marta Maqueda, Ana Elda Rabella, Mireia Rodríguez-Pujadas, Aina Antonijoan Arbós, Rosa Ma (Rosa María) Romero, Sergio Alonso, Joan Francesc Mañanas, Miquel Àngel Barker, Steven Friedlander, Pablo Feilding, Amanda Riba, Jordi Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia Ayahuasca Human Ketanserin Neurophysiological effects Serotonin-(2A) receptor Subjective effects Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus β-carboline alkaloids with monoamine-oxidase (MAO)-inhibiting properties. Although the psychoactive effects of ayahuasca have commonly been attributed solely to agonism at the 5-HT receptor, the molecular target of classical psychedelics, this has not been tested experimentally. Here we wished to study the contribution of the 5-HT receptor to the neurophysiological and psychological effects of ayahuasca in humans. We measured drug-induced changes in spontaneous brain oscillations and subjective effects in a double-blind randomized placebo-controlled study involving the oral administration of ayahuasca (0.75 mg DMT/kg body weight) and the 5-HT antagonist ketanserin (40 mg). Twelve healthy, experienced psychedelic users (5 females) participated in four experimental sessions in which they received the following drug combinations: placebo+placebo, placebo+ayahuasca, ketanserin+placebo and ketanserin+ayahuasca. Ayahuasca induced EEG power decreases in the delta, theta and alpha frequency bands. Current density in alpha-band oscillations in parietal and occipital cortex was inversely correlated with the intensity of visual imagery induced by ayahuasca. Pretreatment with ketanserin inhibited neurophysiological modifications, reduced the correlation between alpha and visual effects, and attenuated the intensity of the subjective experience. These findings suggest that despite the chemical complexity of ayahuasca, 5-HT activation plays a key role in the neurophysiological and visual effects of ayahuasca in humans. 2016 Article European neuropsychopharmacology ; Vol. 26, Núm. 7 (July 2016), p. 1161-1175 open access Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets. https://rightsstatements.org/vocab/InC/1.0/